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And less than 3% currently receive anti-obesity medications (AOMs), so there is a huge unmet need for a treatment like Wegovy to help people lose weight and keep it off. It seems clear why Novo didnt want to wait around

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oral semaglutide based on the PIONEER 2 study [55], the treatment policy estimand for HbA1c impacts was used in the base case, which includes the use of rescue medications (e.g., including insulin)

A Phase 2 trial (NCT01311518) was designed to test RGN-352 in ~75 heart attack patients, but was placed on FDA clinical hold in 2011 due to manufacturing (GMP) compliance issues at the contract site not safety concerns with the drug itself